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<title>Scientific control</title>

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<span id="openzim-page-title" class="mw-page-title-main"><span class="mw-page-title-main">Scientific control</span></span>

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</style><div role="note" class="hatnote navigation-not-searchable">For other uses, see <a href="Control_(disambiguation)" class="mw-redirect mw-disambig" title="Control (disambiguation)">Control</a> and <a href="Treatment_and_control_groups" title="Treatment and control groups">Treatment and control groups</a>.</div>

<p>A <b>scientific control</b> is an <a href="Experiment" title="Experiment">experiment</a> or <a href="Observation" title="Observation">observation</a> designed to minimize the effects of variables other than the <a href="Independent_variable" class="mw-redirect" title="Independent variable">independent variable</a> (i.e. <a href="Confounding_variables" class="mw-redirect" title="Confounding variables">confounding variables</a>).<sup id="cite_ref-EDE_1-0" class="reference"><a href="#cite_note-EDE-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> This increases the reliability of the results, often through a comparison between control measurements and the other measurements. Scientific controls are a part of the <a href="Scientific_method" title="Scientific method">scientific method</a>.

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<div class="mw-heading mw-heading2"><h2 id="Controlled_experiments">Controlled experiments</h2></div>

<div role="note" class="hatnote navigation-not-searchable">See also: <a href="Scientific_method" title="Scientific method">Scientific method</a> and <a href="Experimental_design" class="mw-redirect" title="Experimental design">Experimental design</a></div>

<p>Controls eliminate alternate explanations of experimental results, especially experimental errors and experimenter bias. Many controls are specific to the type of experiment being performed, as in the molecular markers used in <a href="SDS-PAGE" title="SDS-PAGE">SDS-PAGE</a> experiments, and may simply have the purpose of ensuring that the equipment is working properly. The selection and use of proper controls to ensure that experimental results are valid (for example, absence of <a href="Confounding_variables" class="mw-redirect" title="Confounding variables">confounding variables</a>) can be very difficult. Control measurements may also be used for other purposes: for example, a measurement of a microphone's background noise in the absence of a signal allows the noise to be subtracted from later measurements of the signal, thus producing a processed signal of higher quality.

</p><p>For example, if a researcher feeds an experimental <a href="Artificial_sweetener" class="mw-redirect" title="Artificial sweetener">artificial sweetener</a> to sixty laboratories <a href="Rat" title="Rat">rats</a> and observes that ten of them subsequently become sick, the underlying cause could be the sweetener itself or something unrelated. Other variables, which may not be readily obvious, may interfere with the experimental design. For instance, the artificial sweetener might be mixed with a dilutant and it might be the dilutant that causes the effect. To control for the effect of the dilutant, the same test is run twice; once with the artificial sweetener in the dilutant, and another done exactly the same way but using the dilutant alone. Now the experiment is controlled for the dilutant and the experimenter can distinguish between sweetener, dilutant, and non-treatment. Controls are most often necessary where a confounding factor cannot easily be separated from the primary treatments. For example, it may be necessary to use a tractor to spread fertilizer where there is no other practicable way to spread fertilizer. The simplest solution is to have a treatment where a tractor is driven over plots without spreading fertilizer and in that way, the effects of tractor traffic are controlled.

</p><p>The simplest types of control are negative and positive controls, and both are found in many different types of experiments.<sup id="cite_ref-pmid12391395_2-0" class="reference"><a href="#cite_note-pmid12391395-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> These two controls, when both are successful, are usually sufficient to eliminate most potential confounding variables: it means that the experiment produces a negative result when a negative result is expected, and a positive result when a positive result is expected. Other controls include vehicle controls, sham controls and comparative controls.<sup id="cite_ref-pmid12391395_2-1" class="reference"><a href="#cite_note-pmid12391395-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup>

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<div class="mw-heading mw-heading2"><h2 id="Confounding">Confounding</h2></div>

<p><a href="Confounding" title="Confounding">Confounding</a> is a critical issue in observational studies because it can lead to biased or misleading conclusions about relationships between variables. A confounder is an extraneous variable that is related to both the independent variable (treatment or exposure) and the dependent variable (outcome), potentially distorting the true association. If confounding is not properly accounted for, researchers might incorrectly attribute an effect to the exposure when it is actually due to another factor. This can result in incorrect policy recommendations, ineffective interventions, or flawed scientific understanding. For example, in a study examining the relationship between physical activity and heart disease, failure to control for diet, a potential confounder, could lead to an overestimation or underestimation of the true effect of exercise.<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup>

</p><p>Falsification tests are a robustness-checking technique used in observational studies to assess whether observed associations are likely due to <a href="Confounding" title="Confounding">confounding</a>, <a href="Bias_of_an_estimator" title="Bias of an estimator">bias</a>, or model misspecification rather than a true causal effect. These tests help validate findings by applying the same analytical approach to a scenario where no effect is expected. If an association still appears where none should exist, it raises concerns that the primary analysis may suffer from confounding or other biases.

</p><p>Negative controls are one type of falsification tests. The need to use negative controls usually arise in observational studies, when the study design can be questioned because of a potential <a href="Confounding" title="Confounding">confounding</a> mechanism. A Negative control test can reject study design, but it cannot validate them. Either because there might be another confounding mechanism, or because of <a href="Power_(statistics)" title="Power (statistics)">low statistical power</a>. Negative controls are increasingly used in the epidemiology literature,<sup id="cite_ref-:1_4-0" class="reference"><a href="#cite_note-:1-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> but they show promise in social sciences fields<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> such as economics.<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Negative controls are divided into two main categories: Negative Control Exposures (NCEs) and Negative Control Outcomes (NCOs).

</p><p>Lousdal et al.<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> examined the effect of screening participation on death from breast cancer. They hypothesized that screening participants are healthier than non-participants and, therefore, already at baseline have a lower risk of breast-cancer death. Therefore, they used proxies for better health as negative-control outcomes (NCOs) and proxies for healthier behavior as negative-control exposures (NCEs). Death from causes other than breast cancer was taken as NCO, as it is an outcome of better health, not effected by breast cancer screening. Dental care participation was taken to be NCE, as it is assumed to be a good proxy of health attentive behavior.

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<div class="mw-heading mw-heading2"><h2 id="Negative_control">Negative control</h2></div>

<div role="note" class="hatnote navigation-not-searchable">See also: <a href="Placebo-controlled_study" title="Placebo-controlled study">Placebo-controlled study</a></div>

<p>Negative controls are variables that meant to help when the study design is suspected to be invalid because of unmeasured confounders that are correlated with both the treatment and the outcome.<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> Where there are only two possible outcomes, e.g. positive or negative, if the treatment group and the negative control (non-treatment group) both produce a negative result, it can be inferred that the treatment had no effect. If the treatment group and the negative control both produce a positive result, it can be inferred that a <a href="Confounding_variable" class="mw-redirect" title="Confounding variable">confounding variable</a> is involved in the phenomenon under study, and the positive results are not solely due to the treatment.

</p><p>In other examples, outcomes might be measured as lengths, times, percentages, and so forth. In the drug testing example, we could measure the percentage of patients cured. In this case, the treatment is inferred to have no effect when the treatment group and the negative control produce the same results. Some improvement is expected in the placebo group due to the <a href="Placebo_effect" class="mw-redirect" title="Placebo effect">placebo effect</a>, and this result sets the baseline upon which the treatment must improve upon. Even if the treatment group shows improvement, it needs to be compared to the placebo group. If the groups show the same effect, then the treatment was not responsible for the improvement (because the same number of patients were cured in the absence of the treatment). The treatment is only effective if the treatment group shows more improvement than the placebo group.

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<div class="mw-heading mw-heading3"><h3 id="Negative_Control_Exposure_(NCE)">Negative Control Exposure (NCE)</h3></div>

<p>NCE is a variable that should not causally affect the outcome, but may suffer from the same confounding as the exposure-outcome relationship in question. A priori, there should be no statistical association between the NCE and the outcome. If an association is found, then it through the unmeasured confounder, and since the NCE and treatment share the same confounding mechanism, there is an alternative path, apart from the direct path from the treatment to the outcome. In that case, the study design is invalid.

</p><p>For example, Yerushalmy<sup id="cite_ref-:0_9-0" class="reference"><a href="#cite_note-:0-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> used husband's smoking as an NCE. The exposure was maternal smoking; the outcomes were various birth factors, such as incidence of low birth weight, length of pregnancy, and neonatal mortality rates. It is assumed that husband's smoking share common confounders, such household health lifestyle with the pregnant woman's smoking, but it does not causally affect the fetus development. Nonetheless, Yerushalmy found a statistical association, And as a result, it casts doubt on the proposition that cigarette smoking causally interferes with intrauterine development of the fetus.

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<div class="mw-heading mw-heading4"><h4 id="Differences_Between_Negative_Control_Exposures_and_Placebo">Differences Between Negative Control Exposures and Placebo</h4></div>

<p>The term negative controls is used when the study is based on observations, while the <a href="Placebo" title="Placebo">Placebo</a> should be used as a non-treatment in <a href="Randomized_controlled_trial" title="Randomized controlled trial">randomized control trials</a>.

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<div class="mw-heading mw-heading3"><h3 id="Negative_Control_Outcome_(NCO)">Negative Control Outcome (NCO)</h3></div>

<p>Negative Control Outcomes are the more popular type of negative controls. NCO is a variable that is not causally affected by the treatment, but suspected to have a similar confounding mechanism as the treatment-outcome relationship. If the study design is valid, there should be no statistical association between the NCO and the treatment. Thus, an association between them suggest that the design is invalid.

</p><p>For example, Jackson et al.<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> used mortality from all causes outside of influenza season an NCO in a study examining influenza vaccine's effect on influenza-related deaths. A possible confounding mechanism is health status and lifestyle, such as the people who are more healthy in general also tend to take the influenza vaccine. Jackson et al. found that a preferential receipt of vaccine by relatively healthy seniors, and that differences in health status between vaccinated and unvaccinated groups leads to bias in estimates of influenza vaccine effectiveness. In a similar example, when discussing the impact of air pollutants on asthma hospital admissions, Sheppard et al.<sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> et al. used non-elderly appendicitis hospital admissions as NCO.

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<div class="mw-heading mw-heading4"><h4 id="Formal_Conditions">Formal Conditions</h4></div>

<p>Given a treatment <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle A}">

</mstyle>

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<annotation encoding="application/x-tex">{\displaystyle A}</annotation>

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</math></span><img src="./7daff47fa58cdfd29dc333def748ff5fa4c923e3.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.338ex; width:1.743ex; height:2.176ex;" alt="{\displaystyle A}" loading="lazy"></span> and an outcome <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle Y}">

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle Y}</annotation>

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</math></span><img src="./961d67d6b454b4df2301ac571808a3538b3a6d3f.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.171ex; width:1.773ex; height:2.009ex;" alt="{\displaystyle Y}" loading="lazy"></span>, in the presence of a set of control variables <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle X}">

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle X}</annotation>

</semantics>

</math></span><img src="./68baa052181f707c662844a465bfeeb135e82bab.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.338ex; width:1.98ex; height:2.176ex;" alt="{\displaystyle X}" loading="lazy"></span>, and unmeasured confounder <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle U}">

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle U}</annotation>

</semantics>

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle A-Y}</annotation>

</semantics>

</math></span><img src="./c4b0bcb805bd2f52207bc2a1977f6b9e52eb5b80.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.505ex; width:6.357ex; height:2.343ex;" alt="{\displaystyle A-Y}" loading="lazy"></span> relationship. Shi et al.<sup id="cite_ref-:1_4-1" class="reference"><a href="#cite_note-:1-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> presented formal conditions for a negative control outcome <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle {\tilde {Y}}}">

<mover>

</mover>

</mrow>

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle {\tilde {Y}}}</annotation>

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<ol><li><a href="Rubin_causal_model#Stable_unit_treatment_value_assumption_(SUTVA)" title="Rubin causal model">Stable Unit Treatment Value Assumption</a> (SUTVA): For both <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle {Y}}">

</mrow>

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle {Y}}</annotation>

</semantics>

</math></span><img src="./fd8c91526ee8c1bf71d6089e4c05b050c1c0bf6c.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.171ex; width:1.773ex; height:2.009ex;" alt="{\displaystyle {Y}}" loading="lazy"></span> and <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle {\tilde {Y}}}">

<mover>

</mover>

</mrow>

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle {\tilde {Y}}}</annotation>

</semantics>

</math></span><img src="./d75f67b5ba0cecc77060ce9367d5d17d1933d099.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.171ex; width:1.773ex; height:2.509ex;" alt="{\displaystyle {\tilde {Y}}}" loading="lazy"></span> with regard to <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle A=a}">

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle A=a}</annotation>

</semantics>

</math></span><img src="./6509e2e3a7f69da0109d3df052c95bb1c12f1e95.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.338ex; width:6.071ex; height:2.176ex;" alt="{\displaystyle A=a}" loading="lazy"></span>.</li>

<li>Latent Exchangeability: <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle Y^{A=a}\perp A|\;X,U}">

<msup>

</mrow>

</msup>

</mrow>

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle Y^{A=a}\perp A|\;X,U}</annotation>

</semantics>

</math></span><img src="./847ad012566da10da0f57fd3c7fb22d2d25b8fe3.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.838ex; width:16.443ex; height:3.176ex;" alt="{\displaystyle Y^{A=a}\perp A|\;X,U}" loading="lazy"></span> Given <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle X}">

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle X}</annotation>

</semantics>

</math></span><img src="./68baa052181f707c662844a465bfeeb135e82bab.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.338ex; width:1.98ex; height:2.176ex;" alt="{\displaystyle X}" loading="lazy"></span> and <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle U}">

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle U}</annotation>

</semantics>

</math></span><img src="./458a728f53b9a0274f059cd695e067c430956025.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.338ex; width:1.783ex; height:2.176ex;" alt="{\displaystyle U}" loading="lazy"></span>, the <a href="Rubin_causal_model#Potential_outcomes" title="Rubin causal model">potential outcome</a> <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle Y^{A=a}}">

<msup>

</mrow>

</msup>

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle Y^{A=a}}</annotation>

</semantics>

</math></span><img src="./9bf4c299aa546195444a84d3fb9b0aec11711e91.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.171ex; width:5.513ex; height:2.509ex;" alt="{\displaystyle Y^{A=a}}" loading="lazy"></span> is independent of the treatment.</li>

<li>Irrelevancy: Ensures the irrelevancy of the treatment on the NCO.

<msup>

<mover>

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</msup>

<msup>

<mover>

</mover>

</mrow>

<msup>

</msup>

</mrow>

</msup>

<mover>

</mover>

</mrow>

</mrow>

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle {\tilde {Y}}^{A=a}={\tilde {Y}}^{A=a'}={\tilde {Y}}|\;U,X}</annotation>

</semantics>

</math></span><img src="./9c0458fe4dc44e5a41b4652844f092b37fbe31b8.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.838ex; width:25.363ex; height:3.843ex;" alt="{\displaystyle {\tilde {Y}}^{A=a}={\tilde {Y}}^{A=a'}={\tilde {Y}}|\;U,X}" loading="lazy"></span>: There is no causal effect of <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle A}">

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle A}</annotation>

</semantics>

</math></span><img src="./7daff47fa58cdfd29dc333def748ff5fa4c923e3.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.338ex; width:1.743ex; height:2.176ex;" alt="{\displaystyle A}" loading="lazy"></span> on <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle {\tilde {Y}}}">

<mover>

</mover>

</mrow>

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle {\tilde {Y}}}</annotation>

</semantics>

</math></span><img src="./d75f67b5ba0cecc77060ce9367d5d17d1933d099.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.171ex; width:1.773ex; height:2.509ex;" alt="{\displaystyle {\tilde {Y}}}" loading="lazy"></span> given <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle X}">

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle X}</annotation>

</semantics>

</math></span><img src="./68baa052181f707c662844a465bfeeb135e82bab.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.338ex; width:1.98ex; height:2.176ex;" alt="{\displaystyle X}" loading="lazy"></span> and <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle U}">

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle U}</annotation>

</semantics>

<mover>

</mover>

</mrow>

</mrow>

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle {\tilde {Y}}\perp A|\;U,X}</annotation>

</semantics>

</math></span><img src="./39e96d3fb926b4e676bfb6b905ba289c87eca488.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.838ex; width:12.703ex; height:3.176ex;" alt="{\displaystyle {\tilde {Y}}\perp A|\;U,X}" loading="lazy"></span>: There is no causal effect of <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle A}">

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle A}</annotation>

</semantics>

</math></span><img src="./7daff47fa58cdfd29dc333def748ff5fa4c923e3.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.338ex; width:1.743ex; height:2.176ex;" alt="{\displaystyle A}" loading="lazy"></span> on <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle {\tilde {Y}}}">

<mover>

</mover>

</mrow>

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle {\tilde {Y}}}</annotation>

</semantics>

</math></span><img src="./d75f67b5ba0cecc77060ce9367d5d17d1933d099.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.171ex; width:1.773ex; height:2.509ex;" alt="{\displaystyle {\tilde {Y}}}" loading="lazy"></span> given <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle X}">

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle X}</annotation>

</semantics>

</math></span><img src="./68baa052181f707c662844a465bfeeb135e82bab.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.338ex; width:1.98ex; height:2.176ex;" alt="{\displaystyle X}" loading="lazy"></span> and <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle U}">

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle U}</annotation>

</semantics>

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle X}</annotation>

</semantics>

</math></span><img src="./68baa052181f707c662844a465bfeeb135e82bab.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.338ex; width:1.98ex; height:2.176ex;" alt="{\displaystyle X}" loading="lazy"></span> and <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle U}">

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle U}</annotation>

</semantics>

<li>U-Comparability: <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle {\tilde {Y}}\not {\perp }U|\;X}">

<mover>

</mover>

</mrow>

</mpadded>

</mrow>

</mrow>

</mrow>

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle {\tilde {Y}}\not {\perp }U|\;X}</annotation>

</semantics>

</math></span><img src="./2eecbc579e7831c0949af5842dfa560c0b5791d5.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.838ex; width:9.926ex; height:3.176ex;" alt="{\displaystyle {\tilde {Y}}\not {\perp }U|\;X}" loading="lazy"></span> The unmeasured confounders <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle U}">

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle U}</annotation>

</semantics>

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle A}</annotation>

</semantics>

</math></span><img src="./7daff47fa58cdfd29dc333def748ff5fa4c923e3.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.338ex; width:1.743ex; height:2.176ex;" alt="{\displaystyle A}" loading="lazy"></span> and <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle Y}">

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle Y}</annotation>

</semantics>

</math></span><img src="./961d67d6b454b4df2301ac571808a3538b3a6d3f.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.171ex; width:1.773ex; height:2.009ex;" alt="{\displaystyle Y}" loading="lazy"></span> are the same for the association between <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle A}">

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle A}</annotation>

</semantics>

</math></span><img src="./7daff47fa58cdfd29dc333def748ff5fa4c923e3.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.338ex; width:1.743ex; height:2.176ex;" alt="{\displaystyle A}" loading="lazy"></span> and <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle {\tilde {Y}}}">

<mover>

</mover>

</mrow>

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle {\tilde {Y}}}</annotation>

</semantics>

<p>Given assumption 1 - 4, a non-null association between <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle A}">

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle A}</annotation>

</semantics>

</math></span><img src="./7daff47fa58cdfd29dc333def748ff5fa4c923e3.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.338ex; width:1.743ex; height:2.176ex;" alt="{\displaystyle A}" loading="lazy"></span> and <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle {\tilde {Y}}}">

<mover>

</mover>

</mrow>

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle {\tilde {Y}}}</annotation>

</semantics>

</math></span><img src="./d75f67b5ba0cecc77060ce9367d5d17d1933d099.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.171ex; width:1.773ex; height:2.509ex;" alt="{\displaystyle {\tilde {Y}}}" loading="lazy"></span>, can be explained by <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle U}">

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle U}</annotation>

</semantics>

</math></span><img src="./458a728f53b9a0274f059cd695e067c430956025.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.338ex; width:1.783ex; height:2.176ex;" alt="{\displaystyle U}" loading="lazy"></span>, and not by another mechanism. A possible violation of Latent Exchangeability will be when only the people that are influenced by a medicine will take it, even if both <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle X}">

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle X}</annotation>

</semantics>

</math></span><img src="./68baa052181f707c662844a465bfeeb135e82bab.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.338ex; width:1.98ex; height:2.176ex;" alt="{\displaystyle X}" loading="lazy"></span> and <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle U}">

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle U}</annotation>

</semantics>

</math></span><img src="./458a728f53b9a0274f059cd695e067c430956025.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.338ex; width:1.783ex; height:2.176ex;" alt="{\displaystyle U}" loading="lazy"></span> are the same. For example, we would expect that given age and medical history (<span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle X}">

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle X}</annotation>

</semantics>

</math></span><img src="./68baa052181f707c662844a465bfeeb135e82bab.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.338ex; width:1.98ex; height:2.176ex;" alt="{\displaystyle X}" loading="lazy"></span>), general health awareness (<span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle U}">

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle U}</annotation>

</semantics>

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle A}</annotation>

</semantics>

</math></span><img src="./7daff47fa58cdfd29dc333def748ff5fa4c923e3.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.338ex; width:1.743ex; height:2.176ex;" alt="{\displaystyle A}" loading="lazy"></span> influenza vaccine will be independent of potential influenza related deaths <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle {\tilde {Y}}^{A=a}}">

<msup>

<mover>

</mover>

</mrow>

</mrow>

</msup>

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle {\tilde {Y}}^{A=a}}</annotation>

</semantics>

</math></span><img src="./1095bd9a26dc6eac9be1e29a5ebdb20d1e40e194.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.171ex; width:5.386ex; height:3.009ex;" alt="{\displaystyle {\tilde {Y}}^{A=a}}" loading="lazy"></span>. Otherwise, the Latent Exchangeability assumption is violated, and no identification can be made.

</p><p>A violation of Irrelevancy occurs when there is a causal effect of <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle A}">

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle A}</annotation>

</semantics>

</math></span><img src="./7daff47fa58cdfd29dc333def748ff5fa4c923e3.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.338ex; width:1.743ex; height:2.176ex;" alt="{\displaystyle A}" loading="lazy"></span> on <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle {\tilde {Y}}}">

<mover>

</mover>

</mrow>

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle {\tilde {Y}}}</annotation>

</semantics>

</math></span><img src="./d75f67b5ba0cecc77060ce9367d5d17d1933d099.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.171ex; width:1.773ex; height:2.509ex;" alt="{\displaystyle {\tilde {Y}}}" loading="lazy"></span>. For example, we would expect that given <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle X}">

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle X}</annotation>

</semantics>

</math></span><img src="./68baa052181f707c662844a465bfeeb135e82bab.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.338ex; width:1.98ex; height:2.176ex;" alt="{\displaystyle X}" loading="lazy"></span> and <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle U}">

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle U}</annotation>

</semantics>

</math></span><img src="./458a728f53b9a0274f059cd695e067c430956025.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.338ex; width:1.783ex; height:2.176ex;" alt="{\displaystyle U}" loading="lazy"></span>, the influenza vaccine does not influence all-cause mortality. If, however, during the influenza vaccine medical visit, the physician also performs a general physical test, recommends good health habits, and prescribes vitamins and essential drugs. In this case, there is likely a causal effect of <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle A}">

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle A}</annotation>

</semantics>

</math></span><img src="./7daff47fa58cdfd29dc333def748ff5fa4c923e3.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.338ex; width:1.743ex; height:2.176ex;" alt="{\displaystyle A}" loading="lazy"></span> on <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle {\tilde {Y}}}">

<mover>

</mover>

</mrow>

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle {\tilde {Y}}}</annotation>

</semantics>

</math></span><img src="./d75f67b5ba0cecc77060ce9367d5d17d1933d099.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.171ex; width:1.773ex; height:2.509ex;" alt="{\displaystyle {\tilde {Y}}}" loading="lazy"></span> (conditional on <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle X}">

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle X}</annotation>

</semantics>

</math></span><img src="./68baa052181f707c662844a465bfeeb135e82bab.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.338ex; width:1.98ex; height:2.176ex;" alt="{\displaystyle X}" loading="lazy"></span> and <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle U}">

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle U}</annotation>

</semantics>

<mover>

</mover>

</mrow>

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle {\tilde {Y}}}</annotation>

</semantics>

</p><p>U-Comparability is violated when <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle {\tilde {Y}}{\perp }U}">

<mover>

</mover>

</mrow>

</mrow>

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle {\tilde {Y}}{\perp }U}</annotation>

</semantics>

</math></span><img src="./87c74c4dfa40ed3b77fd15d0430edaf3db4dce81.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.338ex; width:5.364ex; height:2.676ex;" alt="{\displaystyle {\tilde {Y}}{\perp }U}" loading="lazy"></span> , and therefore the lack of association between <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle A}">

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle A}</annotation>

</semantics>

</math></span><img src="./7daff47fa58cdfd29dc333def748ff5fa4c923e3.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.338ex; width:1.743ex; height:2.176ex;" alt="{\displaystyle A}" loading="lazy"></span> and <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle {\tilde {Y}}}">

<mover>

</mover>

</mrow>

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle {\tilde {Y}}}</annotation>

</semantics>

</math></span><img src="./d75f67b5ba0cecc77060ce9367d5d17d1933d099.svg" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.171ex; width:1.773ex; height:2.509ex;" alt="{\displaystyle {\tilde {Y}}}" loading="lazy"></span> does not provide us any evidence for the invalidity of <span class="mwe-math-element mwe-math-element-inline"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle A}">

</mstyle>

</mrow>

<annotation encoding="application/x-tex">{\displaystyle A}</annotation>

</semantics>

</p>

<div class="mw-heading mw-heading2"><h2 id="Positive_control">Positive control</h2></div>

<p>

Positive controls are often used to assess <a href="Test_validity" title="Test validity">test validity</a>. For example, to assess a new test's ability to detect a disease (its <a href="Sensitivity_and_specificity" title="Sensitivity and specificity">sensitivity</a>), then we can compare it against a different test that is already known to work. The well-established test is a positive control since we already know that the answer to the question (whether the test works) is yes.

</p><p>Similarly, in an <a href="Enzyme_assay" title="Enzyme assay">enzyme assay</a> to measure the amount of an enzyme in a set of extracts, a positive control would be an assay containing a known quantity of the purified enzyme (while a negative control would contain no enzyme). The positive control should give a large amount of enzyme activity, while the negative control should give very low to no activity.

</p><p>If the positive control does not produce the expected result, there may be something wrong with the experimental procedure, and the experiment is repeated. For difficult or complicated experiments, the result from the positive control can also help in comparison to previous experimental results. For example, if the well-established disease test was determined to have the same effect as found by previous experimenters, this indicates that the experiment is being performed in the same way that the previous experimenters did.

</p><p>When possible, multiple positive controls may be used—if there is more than one disease test that is known to be effective, more than one might be tested. Multiple positive controls also allow finer comparisons of the results (calibration, or standardization) if the expected results from the positive controls have different sizes. For example, in the enzyme assay discussed above, a <a href="Standard_curve" class="mw-redirect" title="Standard curve">standard curve</a> may be produced by making many different samples with different quantities of the enzyme.

</p>

<div class="mw-heading mw-heading2"><h2 id="Randomization">Randomization</h2></div>

<div role="note" class="hatnote navigation-not-searchable">Main article: <a href="Random_assignment" title="Random assignment">Random assignment</a></div>

<p>In randomization, the groups that receive different experimental treatments are determined randomly. While this does not ensure that there are no differences between the groups, it ensures that the differences are distributed equally, thus correcting for <a href="Systematic_error" class="mw-redirect" title="Systematic error">systematic errors</a>.

</p><p>For example, in experiments where <a href="Crop_yield" title="Crop yield">crop yield</a> is affected (e.g. <a href="Soil_fertility" title="Soil fertility">soil fertility</a>), the experiment can be controlled by assigning the treatments to randomly selected plots of land. This mitigates the effect of variations in soil composition on the yield.

</p>

<div class="mw-heading mw-heading2"><h2 id="Blind_experiments">Blind experiments</h2></div>

<div role="note" class="hatnote navigation-not-searchable">Main article: <a href="Blind_experiment" class="mw-redirect" title="Blind experiment">Blind experiment</a></div>

<p>Blinding is the practice of withholding information that may <a href="Bias" title="Bias">bias</a> an experiment. For example, participants may not know who received an active treatment and who received a <a href="Placebo" title="Placebo">placebo</a>. If this information were to become available to trial participants, patients could receive a larger <a href="Placebo_effect" class="mw-redirect" title="Placebo effect">placebo effect</a>, researchers could influence the experiment to meet their expectations (the <a href="Observer-expectancy_effect" title="Observer-expectancy effect">observer effect</a>), and evaluators could be subject to <a href="Confirmation_bias" title="Confirmation bias">confirmation bias</a>. A blind can be imposed on any participant of an experiment, including subjects, researchers, technicians, data analysts, and evaluators. In some cases, <a href="Sham_surgery" title="Sham surgery">sham surgery</a> may be necessary to achieve blinding.

</p><p>During the course of an experiment, a participant becomes <a href="Unblinding" class="mw-redirect" title="Unblinding">unblinded</a> if they deduce or otherwise obtain information that has been masked to them. Unblinding that occurs before the conclusion of a study is a source of experimental error, as the bias that was eliminated by blinding is re-introduced. Unblinding is common in blind experiments and must be measured and reported. <a href="Meta-research" class="mw-redirect" title="Meta-research">Meta-research</a> has revealed high levels of unblinding in pharmacological trials. In particular, <a href="Antidepressant" title="Antidepressant">antidepressant</a> trials are poorly blinded. <a href="Consolidated_Standards_of_Reporting_Trials" title="Consolidated Standards of Reporting Trials">Reporting guidelines</a> recommend that all studies assess and report unblinding. In practice, very few studies assess unblinding.<sup id="cite_ref-Bello2014_12-0" class="reference"><a href="#cite_note-Bello2014-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup>

</p><p>Blinding is an important tool of the <a href="Scientific_method" title="Scientific method">scientific method</a>, and is used in many fields of research. In some fields, such as <a href="Evidence-based_medicine" title="Evidence-based medicine">medicine</a>, it is considered essential.<sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> In clinical research, a trial that is not blinded trial is called an <a href="Open-label_trial" title="Open-label trial">open trial</a>.

</p>

<ul><li><a href="False_positives_and_false_negatives" title="False positives and false negatives">False positives and false negatives</a></li>

<li><a href="Designed_experiment" class="mw-redirect" title="Designed experiment">Designed experiment</a></li>

<li><a href="Controlling_for_a_variable" title="Controlling for a variable">Controlling for a variable</a></li>

<li><a href="James_Lind#Prevention_and_cure_of_scurvy" title="James Lind">James Lind</a></li>

<li><a href="Randomized_controlled_trial" title="Randomized controlled trial">Randomized controlled trial</a></li>

<li><a href="Wait_list_control_group" title="Wait list control group">Wait list control group</a></li></ul>

<div class="mw-heading mw-heading2"><h2 id="References">References</h2></div>

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</style><cite class="citation book cs1"><a rel="nofollow" class="external text" href="https://books.google.com/books?id=1m0_FLEjd-cC"><i>Life, Vol. II: Evolution, Diversity and Ecology: (Chs. 1, 21–33, 52–57)</i></a>. W. H. Freeman. 2006. p. 15. <a href="ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <bdi>978-0-7167-7674-1</bdi><span class="reference-accessdate">. Retrieved <span class="nowrap">14 February</span> 2015</span>.</cite></span>

</li>

<li id="cite_note-pmid12391395-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid12391395_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid12391395_2-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><cite id="CITEREFJohnson_PD,_Besselsen_DG2002" class="citation journal cs1">Johnson PD, Besselsen DG (2002). <a rel="nofollow" class="external text" href="https://web.archive.org/web/20100529013304/http://www.montana.edu/wwwarc/Micro%20501/ILAR%20practical%20exp%20design.pdf">"Practical aspects of experimental design in animal research"</a> <span class="cs1-format">(PDF)</span>. <i>ILAR J</i>. <b>43</b> (4): <span class="nowrap">202–</span>206. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Filar.43.4.202">10.1093/ilar.43.4.202</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12391395">12391395</a>. Archived from <a rel="nofollow" class="external text" href="http://www.montana.edu/wwwarc/Micro%20501/ILAR%20practical%20exp%20design.pdf">the original</a> <span class="cs1-format">(PDF)</span> on 2010-05-29.</cite></span>

</li>

<li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><cite id="CITEREFMannWood2012" class="citation journal cs1">Mann, Bikaramjit; Wood, Evan (2012-05-16). <a rel="nofollow" class="external text" href="https://doi.org/10.2174%2F1874297101205010018">"Confounding in Observational Studies Explained"</a>. <i>The Open Epidemiology Journal</i>. <b>5</b> (1): <span class="nowrap">18–</span>20. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.2174%2F1874297101205010018">10.2174/1874297101205010018</a></span>. <a href="ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/1874-2971">1874-2971</a>.</cite></span>

</li>

<li id="cite_note-:1-4"><span class="mw-cite-backlink">^ <a href="#cite_ref-:1_4-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:1_4-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><cite id="CITEREFShiMiaoTchetgen2020" class="citation journal cs1">Shi, Xu; Miao, Wang; Tchetgen, Eric Tchetgen (2020-10-15). <a rel="nofollow" class="external text" href="https://doi.org/10.1007/s40471-020-00243-4">"A Selective Review of Negative Control Methods in Epidemiology"</a>. <i>Current Epidemiology Reports</i>. <b>7</b> (4): <span class="nowrap">190–</span>202. <a href="ArXiv_(identifier)" class="mw-redirect" title="ArXiv (identifier)">arXiv</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://arxiv.org/abs/2009.05641">2009.05641</a></span>. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs40471-020-00243-4">10.1007/s40471-020-00243-4</a>. <a href="ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/2196-2995">2196-2995</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118596">8118596</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/33996381">33996381</a>.</cite></span>

</li>

<li id="cite_note-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-5">^</a></b></span> <span class="reference-text"><cite id="CITEREFShrout1980" class="citation journal cs1">Shrout, Patrick E. (January 1980). <span class="id-lock-subscription" title="Paid subscription required"><a rel="nofollow" class="external text" href="https://doi.org/10.1016/0149-7189(80)90063-4">"Quasi-experimentation: Design and analysis issues for field settings"</a></span>. <i>Evaluation and Program Planning</i>. <b>3</b> (2): <span class="nowrap">145–</span>147. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0149-7189%2880%2990063-4">10.1016/0149-7189(80)90063-4</a>. <a href="ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/0149-7189">0149-7189</a>.</cite></span>

</li>

<li id="cite_note-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-6">^</a></b></span> <span class="reference-text"><cite id="CITEREFDanieliNevoWalkWeinstein2024" class="citation cs2">Danieli, Oren; Nevo, Daniel; Walk, Itai; Weinstein, Bar; Zeltzer, Dan (2024-05-09), <i>Negative Control Falsification Tests for Instrumental Variable Designs</i>, <a href="ArXiv_(identifier)" class="mw-redirect" title="ArXiv (identifier)">arXiv</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://arxiv.org/abs/2312.15624">2312.15624</a></span></cite></span>

</li>

<li id="cite_note-7"><span class="mw-cite-backlink"><b><a href="#cite_ref-7">^</a></b></span> <span class="reference-text"><cite id="CITEREFLousdalLashFlandersBrookhart2020" class="citation journal cs1">Lousdal, Mette Lise; Lash, Timothy L; Flanders, W Dana; Brookhart, M Alan; Kristiansen, Ivar Sønbø; Kalager, Mette; Støvring, Henrik (2020-03-25). <a rel="nofollow" class="external text" href="https://doi.org/10.1093/ije/dyaa029">"Negative controls to detect uncontrolled confounding in observational studies of mammographic screening comparing participants and non-participants"</a>. <i>International Journal of Epidemiology</i>. <b>49</b> (3): <span class="nowrap">1032–</span>1042. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fije%2Fdyaa029">10.1093/ije/dyaa029</a>. <a href="ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/0300-5771">0300-5771</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394947">7394947</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/32211885">32211885</a>.</cite></span>

</li>

<li id="cite_note-8"><span class="mw-cite-backlink"><b><a href="#cite_ref-8">^</a></b></span> <span class="reference-text"><cite id="CITEREFLipsitchTchetgen_TchetgenCohen2010" class="citation journal cs1">Lipsitch, Marc; Tchetgen Tchetgen, Eric; Cohen, Ted (May 2010). <a rel="nofollow" class="external text" href="https://doi.org/10.1097/ede.0b013e3181d61eeb">"Negative Controls"</a>. <i>Epidemiology</i>. <b>21</b> (3): <span class="nowrap">383–</span>388. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1097%2Fede.0b013e3181d61eeb">10.1097/ede.0b013e3181d61eeb</a>. <a href="ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/1044-3983">1044-3983</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053408">3053408</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/20335814">20335814</a>.</cite></span>

</li>

<li id="cite_note-:0-9"><span class="mw-cite-backlink"><b><a href="#cite_ref-:0_9-0">^</a></b></span> <span class="reference-text"><cite id="CITEREFYerushalmy2014" class="citation journal cs1">Yerushalmy, J (October 2014). <span class="id-lock-subscription" title="Paid subscription required"><a rel="nofollow" class="external text" href="https://doi.org/10.1093/ije/dyu160">"The relationship of parents' cigarette smoking to outcome of pregnancy—implications as to the problem of inferring causation from observed associations1"</a></span>. <i>International Journal of Epidemiology</i>. <b>43</b> (5): <span class="nowrap">1355–</span>1366. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fije%2Fdyu160">10.1093/ije/dyu160</a>. <a href="ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/1464-3685">1464-3685</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/25301860">25301860</a>.</cite></span>

</li>

<li id="cite_note-10"><span class="mw-cite-backlink"><b><a href="#cite_ref-10">^</a></b></span> <span class="reference-text"><cite id="CITEREFJacksonJacksonNelsonNeuzil2005" class="citation journal cs1">Jackson, Lisa A; Jackson, Michael L; Nelson, Jennifer C; Neuzil, Kathleen M; Weiss, Noel S (2005-12-20). <a rel="nofollow" class="external text" href="https://doi.org/10.1093/ije/dyi274">"Evidence of bias in estimates of influenza vaccine effectiveness in seniors"</a>. <i>International Journal of Epidemiology</i>. <b>35</b> (2): <span class="nowrap">337–</span>344. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fije%2Fdyi274">10.1093/ije/dyi274</a>. <a href="ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/1464-3685">1464-3685</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16368725">16368725</a>.</cite></span>

</li>

<li id="cite_note-11"><span class="mw-cite-backlink"><b><a href="#cite_ref-11">^</a></b></span> <span class="reference-text"><cite id="CITEREFSheppardLevyNorrisLarson1999" class="citation journal cs1">Sheppard, Lianne; Levy, Drew; Norris, Gary; Larson, Timothy V.; Koenig, Jane Q. (January 1999). <span class="id-lock-subscription" title="Paid subscription required"><a rel="nofollow" class="external text" href="https://doi.org/10.1097/00001648-199901000-00006">"Effects of Ambient Air Pollution on Nonelderly Asthma Hospital Admissions in Seattle, Washington, 1987–1994"</a></span>. <i>Epidemiology</i>. <b>10</b> (1): <span class="nowrap">23–</span>30. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1097%2F00001648-199901000-00006">10.1097/00001648-199901000-00006</a>. <a href="ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/1044-3983">1044-3983</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9888276">9888276</a>.</cite></span>

</li>

<li id="cite_note-Bello2014-12"><span class="mw-cite-backlink"><b><a href="#cite_ref-Bello2014_12-0">^</a></b></span> <span class="reference-text"><cite id="CITEREFBelloMoustgaardHróbjartsson2014" class="citation journal cs1">Bello, Segun; Moustgaard, Helene; Hróbjartsson, Asbjørn (October 2014). "The risk of unblinding was infrequently and incompletely reported in 300 randomized clinical trial publications". <i>Journal of Clinical Epidemiology</i>. <b>67</b> (10): <span class="nowrap">1059–</span>1069. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.jclinepi.2014.05.007">10.1016/j.jclinepi.2014.05.007</a>. <a href="ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/1878-5921">1878-5921</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/24973822">24973822</a>.</cite></span>

</li>

<li id="cite_note-13"><span class="mw-cite-backlink"><b><a href="#cite_ref-13">^</a></b></span> <span class="reference-text"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.cebm.net/oxford-centre-evidence-based-medicine-levels-evidence-march-2009/">"Oxford Centre for Evidence-based Medicine – Levels of Evidence (March 2009)"</a>. <i>cebm.net</i>. 11 June 2009. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20171026195451/http://www.cebm.net/oxford-centre-evidence-based-medicine-levels-evidence-march-2009/">Archived</a> from the original on 26 October 2017<span class="reference-accessdate">. Retrieved <span class="nowrap">2 May</span> 2018</span>.</cite></span>

</li>

</ol></div>

<div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2></div>

<ul><li><cite class="citation encyclopaedia cs1"><span class="cs1-ws-icon" title="s:1911 Encyclopædia Britannica/Control"><a class="external text external" href="https://en.wikisource.org/wiki/1911_Encyclop%C3%A6dia_Britannica/Control">"Control" </a></span>. <i><a href="Encyclop%C3%A6dia_Britannica_Eleventh_Edition" title="Encyclopædia Britannica Eleventh Edition">Encyclopædia Britannica</a></i>. Vol. 7 (11th ed.). 1911.</cite></li></ul>

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</style><div id="Clinical_research_and_experimental_design505" style="font-size:114%;margin:0 4em"><a href="Clinical_research" title="Clinical research">Clinical research</a> and <a href="Design_of_experiments" title="Design of experiments">experimental design</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Overview</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Clinical_trial" title="Clinical trial">Clinical trial</a>

<ul><li><a href="Protocol_(science)" title="Protocol (science)">Trial protocols</a></li>

<li><a href="Adaptive_clinical_trial" class="mw-redirect" title="Adaptive clinical trial">Adaptive clinical trial</a></li></ul></li>

<li><a href="Academic_clinical_trials" class="mw-redirect" title="Academic clinical trials">Academic clinical trials</a></li>

<li><a href="Clinical_study_design" title="Clinical study design">Clinical study design</a></li>

<li><a href="Evidence-based_medicine" title="Evidence-based medicine">Evidence-based medicine</a></li>

<li><a href="Real_world_evidence" title="Real world evidence">Real world evidence</a></li>

<li><a href="Patient_and_public_involvement" title="Patient and public involvement">Patient and public involvement</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><br>(<a href="Hierarchy_of_evidence#USA" title="Hierarchy of evidence">EBM I to II-1</a>)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Randomized_controlled_trial" title="Randomized controlled trial">Randomized controlled trial</a>

<ul><li><a href="Experiment" title="Experiment">Scientific experiment</a></li>

<li><a href="Blind_experiment" class="mw-redirect" title="Blind experiment">Blind experiment</a></li>

<li><a href="Open-label_trial" title="Open-label trial">Open-label trial</a></li></ul></li>

<li><a href="Adaptive_clinical_trial" class="mw-redirect" title="Adaptive clinical trial">Adaptive clinical trial</a>

<ul><li><a href="Platform_trial" title="Platform trial">Platform trial</a></li></ul></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Observational_study" title="Observational study">Observational study</a><br>(<a href="Hierarchy_of_evidence#USA" title="Hierarchy of evidence">EBM II-2 to II-3</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Cross-sectional_study" title="Cross-sectional study">Cross-sectional study</a> vs. <a href="Longitudinal_study" title="Longitudinal study">Longitudinal study</a>, <a href="Ecological_study" title="Ecological study">Ecological study</a></li>

<li><a href="Cohort_study" title="Cohort study">Cohort study</a>

<ul><li><a href="Retrospective_cohort_study" title="Retrospective cohort study">Retrospective</a></li>

<li><a href="Prospective_cohort_study" title="Prospective cohort study">Prospective</a></li></ul></li>

<li><a href="Case%E2%80%93control_study" title="Case–control study">Case–control study</a> (<a href="Nested_case%E2%80%93control_study" title="Nested case–control study">Nested case–control study</a>)</li>

<li><a href="Case_series" title="Case series">Case series</a></li>

<li><a href="Case_study" title="Case study">Case study</a></li>

<li><a href="Case_report" title="Case report">Case report</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Outcome_measure" title="Outcome measure">Measures</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Epidemiological_methods" class="mw-redirect" title="Epidemiological methods">Occurrence</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="Incidence_(epidemiology)" title="Incidence (epidemiology)">Incidence</a>, <a href="Cumulative_incidence" class="mw-redirect" title="Cumulative incidence">Cumulative incidence</a>, <a href="Prevalence" title="Prevalence">Prevalence</a>, <a href="Point_prevalence" class="mw-redirect" title="Point prevalence">Point prevalence</a>, <a href="Period_prevalence" class="mw-redirect" title="Period prevalence">Period prevalence</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Epidemiological_methods" class="mw-redirect" title="Epidemiological methods">Association</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="Risk_difference" title="Risk difference">Risk difference</a>, <a href="Number_needed_to_treat" title="Number needed to treat">Number needed to treat</a>, <a href="Number_needed_to_harm" title="Number needed to harm">Number needed to harm</a>, <a href="Risk_ratio" class="mw-redirect" title="Risk ratio">Risk ratio</a>, <a href="Relative_risk_reduction" title="Relative risk reduction">Relative risk reduction</a>, <a href="Odds_ratio" title="Odds ratio">Odds ratio</a>, <a href="Hazard_ratio" title="Hazard ratio">Hazard ratio</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Population_impact_measure" title="Population impact measure">Population impact</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="Attributable_fraction_among_the_exposed" title="Attributable fraction among the exposed">Attributable fraction among the exposed</a>, <a href="Attributable_fraction_for_the_population" title="Attributable fraction for the population">Attributable fraction for the population</a>, <a href="Preventable_fraction_among_the_unexposed" title="Preventable fraction among the unexposed">Preventable fraction among the unexposed</a>, <a href="Preventable_fraction_for_the_population" title="Preventable fraction for the population">Preventable fraction for the population</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Epidemiological_methods" class="mw-redirect" title="Epidemiological methods">Other</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="Clinical_endpoint" title="Clinical endpoint">Clinical endpoint</a>, <a href="Virulence" title="Virulence">Virulence</a>, <a href="Infectivity" title="Infectivity">Infectivity</a>, <a href="Mortality_rate" title="Mortality rate">Mortality rate</a>, <a href="Morbidity" class="mw-redirect" title="Morbidity">Morbidity</a>, <a href="Case_fatality_rate" title="Case fatality rate">Case fatality rate</a>, <a href="Specificity_and_sensitivity" class="mw-redirect" title="Specificity and sensitivity">Specificity and sensitivity</a>, <a href="Likelihood_ratios_in_diagnostic_testing" title="Likelihood ratios in diagnostic testing">Likelihood-ratios</a>, <a href="Pre-_and_post-test_probability" title="Pre- and post-test probability">Pre- and post-test probability</a></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Trial/test types</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="In_vitro" title="In vitro">In vitro</a></li>

<li><a href="Animal_testing" title="Animal testing">Animal testing</a></li>

<li><a href="Animal_testing_on_non-human_primates" title="Animal testing on non-human primates">Animal testing on non-human primates</a></li>

<li><a href="First-in-man_study" class="mw-redirect" title="First-in-man study">First-in-man study</a></li>

<li><a href="Multicenter_trial" title="Multicenter trial">Multicenter trial</a></li>

<li><a href="Seeding_trial" title="Seeding trial">Seeding trial</a></li>

<li><a href="Vaccine_trial" title="Vaccine trial">Vaccine trial</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Analysis_of_clinical_trials" title="Analysis of clinical trials">Analysis of clinical trials</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Risk%E2%80%93benefit_ratio" title="Risk–benefit ratio">Risk–benefit ratio</a></li>

<li><a href="Systematic_review" title="Systematic review">Systematic review</a></li>

<li><a href="Reproducibility" title="Reproducibility">Replication</a></li>

<li><a href="Meta-analysis" title="Meta-analysis">Meta-analysis</a></li>

<li><a href="Intention-to-treat_analysis" title="Intention-to-treat analysis">Intention-to-treat analysis</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Interpretation of results</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Selection_bias" title="Selection bias">Selection bias</a></li>

<li><a href="Survivorship_bias" title="Survivorship bias">Survivorship bias</a></li>

<li><a href="Correlation_does_not_imply_causation" title="Correlation does not imply causation">Correlation does not imply causation</a></li>

<li><a href="Null_result" title="Null result">Null result</a></li>

<li><a href="Sex_as_a_biological_variable" title="Sex as a biological variable">Sex as a biological variable</a></li></ul>

</div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div>

<ul><li><b>Category</b></li>

<li><b><a href="Glossary_of_clinical_research" title="Glossary of clinical research">Glossary</a></b></li>

<li><b><a href="List_of_clinical_research_topics" class="mw-redirect" title="List of clinical research topics">List of topics</a></b></li></ul>

</div></td></tr></tbody></table></div>

<div class="navbox-styles"></div><div role="navigation" class="navbox" aria-labelledby="Statistics654" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Statistics654" style="font-size:114%;margin:0 4em"><a href="Statistics" title="Statistics">Statistics</a></div></th></tr><tr><td class="navbox-abovebelow" colspan="2"><div>

<ul><li><a href="Outline_of_statistics" title="Outline of statistics">Outline</a></li>

<li><a href="List_of_statistics_articles" title="List of statistics articles">Index</a></li></ul>

</div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Descriptive_statistics654" style="font-size:114%;margin:0 4em"><a href="Descriptive_statistics" title="Descriptive statistics">Descriptive statistics</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Continuous_probability_distribution" class="mw-redirect" title="Continuous probability distribution">Continuous data</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;font-weight:normal;"><a href="Central_tendency" title="Central tendency">Center</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Arithmetic_mean" title="Arithmetic mean">Arithmetic</a></li>

<li><a href="Arithmetic%E2%80%93geometric_mean" title="Arithmetic–geometric mean">Arithmetic-Geometric</a></li>

<li><a href="Contraharmonic_mean" title="Contraharmonic mean">Contraharmonic</a></li>

<li><a href="Cubic_mean" title="Cubic mean">Cubic</a></li>

<li><a href="Generalized_mean" title="Generalized mean">Generalized/power</a></li>

<li><a href="Geometric_mean" title="Geometric mean">Geometric</a></li>

<li><a href="Harmonic_mean" title="Harmonic mean">Harmonic</a></li>

<li><a href="Heronian_mean" title="Heronian mean">Heronian</a></li>

<li><a href="Heinz_mean" title="Heinz mean">Heinz</a></li>

<li><a href="Lehmer_mean" title="Lehmer mean">Lehmer</a></li></ul></li>

<li><a href="Median" title="Median">Median</a></li>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;font-weight:normal;"><a href="Statistical_dispersion" title="Statistical dispersion">Dispersion</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Average_absolute_deviation" title="Average absolute deviation">Average absolute deviation</a></li>

<li><a href="Coefficient_of_variation" title="Coefficient of variation">Coefficient of variation</a></li>

<li><a href="Interquartile_range" title="Interquartile range">Interquartile range</a></li>

<li><a href="Percentile" title="Percentile">Percentile</a></li>

<li><a href="Range_(statistics)" title="Range (statistics)">Range</a></li>

<li><a href="Standard_deviation" title="Standard deviation">Standard deviation</a></li>

<li><a href="Variance#Sample_variance" title="Variance">Variance</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;font-weight:normal;"><a href="Shape_of_the_distribution" class="mw-redirect" title="Shape of the distribution">Shape</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Central_limit_theorem" title="Central limit theorem">Central limit theorem</a></li>

<li><a href="Moment_(mathematics)" title="Moment (mathematics)">Moments</a>

<ul><li><a href="Kurtosis" title="Kurtosis">Kurtosis</a></li>

<li><a href="L-moment" title="L-moment">L-moments</a></li>

<li><a href="Skewness" title="Skewness">Skewness</a></li></ul></li></ul>

</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Count_data" title="Count data">Count data</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Index_of_dispersion" title="Index of dispersion">Index of dispersion</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em">Summary tables</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Contingency_table" title="Contingency table">Contingency table</a></li>

<li><a href="Frequency_distribution" class="mw-redirect" title="Frequency distribution">Frequency distribution</a></li>

<li><a href="Grouped_data" title="Grouped data">Grouped data</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Correlation_and_dependence" class="mw-redirect" title="Correlation and dependence">Dependence</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Partial_correlation" title="Partial correlation">Partial correlation</a></li>

<li><a href="Pearson_correlation_coefficient" title="Pearson correlation coefficient">Pearson product-moment correlation</a></li>

<li><a href="Rank_correlation" title="Rank correlation">Rank correlation</a>

<ul><li><a href="Kendall_rank_correlation_coefficient" title="Kendall rank correlation coefficient">Kendall's τ</a></li>

<li><a href="Spearman's_rank_correlation_coefficient" title="Spearman's rank correlation coefficient">Spearman's ρ</a></li></ul></li>

<li><a href="Scatter_plot" title="Scatter plot">Scatter plot</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Statistical_graphics" title="Statistical graphics">Graphics</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Bar_chart" title="Bar chart">Bar chart</a></li>

<li><a href="Biplot" title="Biplot">Biplot</a></li>

<li><a href="Control_chart" title="Control chart">Control chart</a></li>

<li><a href="Correlogram" title="Correlogram">Correlogram</a></li>

<li><a href="Fan_chart_(statistics)" title="Fan chart (statistics)">Fan chart</a></li>

<li><a href="Forest_plot" title="Forest plot">Forest plot</a></li>

<li><a href="Histogram" title="Histogram">Histogram</a></li>

<li><a href="Pie_chart" title="Pie chart">Pie chart</a></li>

<li><a href="Radar_chart" title="Radar chart">Radar chart</a></li>

<li><a href="Run_chart" title="Run chart">Run chart</a></li>

<li><a href="Scatter_plot" title="Scatter plot">Scatter plot</a></li>

<li><a href="Stem-and-leaf_display" title="Stem-and-leaf display">Stem-and-leaf display</a></li>

<li><a href="Violin_plot" title="Violin plot">Violin plot</a></li></ul>

</div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible uncollapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Data_collection654" style="font-size:114%;margin:0 4em"><a href="Data_collection" title="Data collection">Data collection</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Design_of_experiments" title="Design of experiments">Study design</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Effect_size" title="Effect size">Effect size</a></li>

<li><a href="Missing_data" title="Missing data">Missing data</a></li>

<li><a href="Optimal_design" class="mw-redirect" title="Optimal design">Optimal design</a></li>

<li><a href="Statistical_population" title="Statistical population">Population</a></li>

<li><a href="Replication_(statistics)" title="Replication (statistics)">Replication</a></li>

<li><a href="Sample_size_determination" title="Sample size determination">Sample size determination</a></li>

<li><a href="Statistic" title="Statistic">Statistic</a></li>

<li><a href="Statistical_power" class="mw-redirect" title="Statistical power">Statistical power</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Survey_methodology" title="Survey methodology">Survey methodology</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Sampling_(statistics)" title="Sampling (statistics)">Sampling</a>

<ul><li><a href="Cluster_sampling" title="Cluster sampling">Cluster</a></li>

<li><a href="Stratified_sampling" title="Stratified sampling">Stratified</a></li></ul></li>

<li><a href="Opinion_poll" title="Opinion poll">Opinion poll</a></li>

<li><a href="Questionnaire" title="Questionnaire">Questionnaire</a></li>

<li><a href="Standard_error" title="Standard error">Standard error</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Experiment" title="Experiment">Controlled experiments</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Blocking_(statistics)" title="Blocking (statistics)">Blocking</a></li>

<li><a href="Factorial_experiment" title="Factorial experiment">Factorial experiment</a></li>

<li><a href="Interaction_(statistics)" title="Interaction (statistics)">Interaction</a></li>

<li><a href="Random_assignment" title="Random assignment">Random assignment</a></li>

<li><a href="Randomized_controlled_trial" title="Randomized controlled trial">Randomized controlled trial</a></li>

<li><a href="Randomized_experiment" title="Randomized experiment">Randomized experiment</a></li>

</ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em">Adaptive designs</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Adaptive_clinical_trial" class="mw-redirect" title="Adaptive clinical trial">Adaptive clinical trial</a></li>

<li><a href="Stochastic_approximation" title="Stochastic approximation">Stochastic approximation</a></li>

<li><a href="Up-and-Down_Designs" class="mw-redirect" title="Up-and-Down Designs">Up-and-down designs</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Observational_study" title="Observational study">Observational studies</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Cohort_study" title="Cohort study">Cohort study</a></li>

<li><a href="Cross-sectional_study" title="Cross-sectional study">Cross-sectional study</a></li>

<li><a href="Natural_experiment" title="Natural experiment">Natural experiment</a></li>

<li><a href="Quasi-experiment" title="Quasi-experiment">Quasi-experiment</a></li></ul>

</div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Statistical_inference654" style="font-size:114%;margin:0 4em"><a href="Statistical_inference" title="Statistical inference">Statistical inference</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Statistical_theory" title="Statistical theory">Statistical theory</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Population_(statistics)" class="mw-redirect" title="Population (statistics)">Population</a></li>

<li><a href="Statistic" title="Statistic">Statistic</a></li>

<li><a href="Probability_distribution" title="Probability distribution">Probability distribution</a></li>

<li><a href="Sampling_distribution" title="Sampling distribution">Sampling distribution</a>

<ul><li><a href="Order_statistic" title="Order statistic">Order statistic</a></li></ul></li>

<li><a href="Empirical_distribution_function" title="Empirical distribution function">Empirical distribution</a>

<ul><li><a href="Density_estimation" title="Density estimation">Density estimation</a></li></ul></li>

<li><a href="Statistical_model" title="Statistical model">Statistical model</a>

<ul><li><a href="Model_specification" class="mw-redirect" title="Model specification">Model specification</a></li>

<li><a href="Lp_space" title="Lp space">L<sup><i>p</i></sup> space</a></li></ul></li>

<li><a href="Statistical_parameter" title="Statistical parameter">Parameter</a>

<ul><li><a href="Location_parameter" title="Location parameter">location</a></li>

<li><a href="Scale_parameter" title="Scale parameter">scale</a></li>

<li><a href="Shape_parameter" title="Shape parameter">shape</a></li></ul></li>

<li><a href="Parametric_statistics" title="Parametric statistics">Parametric family</a>

<ul><li><a href="Likelihood_function" title="Likelihood function">Likelihood</a> <a href="Monotone_likelihood_ratio" title="Monotone likelihood ratio"><span style="font-size: 85%;">(monotone)</span></a></li>

<li><a href="Location%E2%80%93scale_family" title="Location–scale family">Location–scale family</a></li>

<li><a href="Exponential_family" title="Exponential family">Exponential family</a></li></ul></li>

<li><a href="Completeness_(statistics)" title="Completeness (statistics)">Completeness</a></li>

<li><a href="Sufficient_statistic" title="Sufficient statistic">Sufficiency</a></li>

<li><a href="Plug-in_principle" class="mw-redirect" title="Plug-in principle">Statistical functional</a>

<ul><li><a href="Bootstrapping_(statistics)" title="Bootstrapping (statistics)">Bootstrap</a></li>

<li><a href="Optimal_decision" title="Optimal decision">Optimal decision</a>

<ul><li><a href="Loss_function" title="Loss function">loss function</a></li></ul></li>

<li><a href="Efficiency_(statistics)" title="Efficiency (statistics)">Efficiency</a></li>

<li><a href="Statistical_distance" title="Statistical distance">Statistical distance</a>

<ul><li><a href="Divergence_(statistics)" title="Divergence (statistics)">divergence</a></li></ul></li>

<li><a href="Asymptotic_theory_(statistics)" title="Asymptotic theory (statistics)">Asymptotics</a></li>

<li><a href="Robust_statistics" title="Robust statistics">Robustness</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Frequentist_inference" title="Frequentist inference">Frequentist inference</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;font-weight:normal;"><a href="Point_estimation" title="Point estimation">Point estimation</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Estimating_equations" title="Estimating equations">Estimating equations</a>

<ul><li><a href="Maximum_likelihood" class="mw-redirect" title="Maximum likelihood">Maximum likelihood</a></li>

<li><a href="Method_of_moments_(statistics)" title="Method of moments (statistics)">Method of moments</a></li>

<li><a href="M-estimator" title="M-estimator">M-estimator</a></li>

<li><a href="Minimum_distance_estimation" class="mw-redirect" title="Minimum distance estimation">Minimum distance</a></li></ul></li>

<li><a href="Bias_of_an_estimator" title="Bias of an estimator">Unbiased estimators</a>

<ul><li><a href="Minimum-variance_unbiased_estimator" title="Minimum-variance unbiased estimator">Mean-unbiased minimum-variance</a>

<ul><li><a href="Rao%E2%80%93Blackwell_theorem" title="Rao–Blackwell theorem">Rao–Blackwellization</a></li>

<li><a href="Lehmann%E2%80%93Scheff%C3%A9_theorem" title="Lehmann–Scheffé theorem">Lehmann–Scheffé theorem</a></li></ul></li>

<li><a href="Median-unbiased_estimator" class="mw-redirect" title="Median-unbiased estimator">Median unbiased</a></li></ul></li>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;font-weight:normal;"><a href="Interval_estimation" title="Interval estimation">Interval estimation</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Confidence_interval" title="Confidence interval">Confidence interval</a></li>

<li><a href="Pivotal_quantity" title="Pivotal quantity">Pivot</a></li>

<li><a href="Likelihood_interval" class="mw-redirect" title="Likelihood interval">Likelihood interval</a></li>

<li><a href="Prediction_interval" title="Prediction interval">Prediction interval</a></li>

<li><a href="Tolerance_interval" title="Tolerance interval">Tolerance interval</a></li>

<li><a href="Resampling_(statistics)" title="Resampling (statistics)">Resampling</a>

<ul><li><a href="Bootstrapping_(statistics)" title="Bootstrapping (statistics)">Bootstrap</a></li>

<li><a href="Jackknife_resampling" title="Jackknife resampling">Jackknife</a></li></ul></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;font-weight:normal;"><a href="Statistical_hypothesis_testing" class="mw-redirect" title="Statistical hypothesis testing">Testing hypotheses</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="One-_and_two-tailed_tests" title="One- and two-tailed tests">1- & 2-tails</a></li>

<li><a href="Power_(statistics)" title="Power (statistics)">Power</a>

<ul><li><a href="Uniformly_most_powerful_test" title="Uniformly most powerful test">Uniformly most powerful test</a></li></ul></li>

<li><a href="Permutation_test" title="Permutation test">Permutation test</a>

<ul><li><a href="Randomization_test" class="mw-redirect" title="Randomization test">Randomization test</a></li></ul></li>

<li><a href="Multiple_comparisons" class="mw-redirect" title="Multiple comparisons">Multiple comparisons</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;font-weight:normal;"><a href="Parametric_statistics" title="Parametric statistics">Parametric tests</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Likelihood-ratio_test" title="Likelihood-ratio test">Likelihood-ratio</a></li>

<li><a href="Score_test" title="Score test">Score/Lagrange multiplier</a></li>

</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="List_of_statistical_tests" title="List of statistical tests">Specific tests</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Z-test" title="Z-test"><i>Z</i>-test <span style="font-size: 85%;">(normal)</span></a></li>

<li><a href="Student's_t-test" title="Student's t-test">Student's <i>t</i>-test</a></li>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;font-weight:normal;"><a href="Goodness_of_fit" title="Goodness of fit">Goodness of fit</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Chi-squared_test" title="Chi-squared test">Chi-squared</a></li>

<li><a href="Kolmogorov%E2%80%93Smirnov_test" title="Kolmogorov–Smirnov test">Kolmogorov–Smirnov</a></li>

<li><a href="Anderson%E2%80%93Darling_test" title="Anderson–Darling test">Anderson–Darling</a></li>

<li><a href="Lilliefors_test" title="Lilliefors test">Lilliefors</a></li>

<li><a href="Jarque%E2%80%93Bera_test" title="Jarque–Bera test">Jarque–Bera</a></li>

<li><a href="Shapiro%E2%80%93Wilk_test" title="Shapiro–Wilk test">Normality <span style="font-size: 85%;">(Shapiro–Wilk)</span></a></li>

<li><a href="Likelihood-ratio_test" title="Likelihood-ratio test">Likelihood-ratio test</a></li>

<li><a href="Model_selection" title="Model selection">Model selection</a>

<ul><li><a href="Cross-validation_(statistics)" title="Cross-validation (statistics)">Cross validation</a></li>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;font-weight:normal;"><a href="Rank_statistics" class="mw-redirect" title="Rank statistics">Rank statistics</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Sample_median" class="mw-redirect" title="Sample median">Sample median</a></li></ul></li>

<li><a href="Wilcoxon_signed-rank_test" title="Wilcoxon signed-rank test">Signed rank <span style="font-size: 85%;">(Wilcoxon)</span></a>

<ul><li><a href="Hodges%E2%80%93Lehmann_estimator" title="Hodges–Lehmann estimator">Hodges–Lehmann estimator</a></li></ul></li>

<li><a href="Mann%E2%80%93Whitney_U_test" title="Mann–Whitney U test">Rank sum <span style="font-size: 85%;">(Mann–Whitney)</span></a></li>

<li><a href="Nonparametric_statistics" title="Nonparametric statistics">Nonparametric</a> <a href="Analysis_of_variance" title="Analysis of variance">anova</a>

<ul><li><a href="Kruskal%E2%80%93Wallis_test" title="Kruskal–Wallis test">1-way <span style="font-size: 85%;">(Kruskal–Wallis)</span></a></li>

<li><a href="Friedman_test" title="Friedman test">2-way <span style="font-size: 85%;">(Friedman)</span></a></li>

<li><a href="Jonckheere's_trend_test" title="Jonckheere's trend test">Ordered alternative <span style="font-size: 85%;">(Jonckheere–Terpstra)</span></a></li></ul></li>

<li><a href="Van_der_Waerden_test" title="Van der Waerden test">Van der Waerden test</a></li></ul>

</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Bayesian_inference" title="Bayesian inference">Bayesian inference</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Bayesian_probability" title="Bayesian probability">Bayesian probability</a>

<ul><li><a href="Prior_probability" title="Prior probability">prior</a></li>

<li><a href="Posterior_probability" title="Posterior probability">posterior</a></li></ul></li>

<li><a href="Credible_interval" title="Credible interval">Credible interval</a></li>

<li><a href="Bayes_factor" title="Bayes factor">Bayes factor</a></li>

<li><a href="Bayes_estimator" title="Bayes estimator">Bayesian estimator</a>

<ul><li><a href="Maximum_a_posteriori_estimation" title="Maximum a posteriori estimation">Maximum posterior estimator</a></li></ul></li></ul>

</div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="CorrelationRegression_analysis654" style="font-size:114%;margin:0 4em"><div class="hlist"><ul><li><a href="Correlation_and_dependence" class="mw-redirect" title="Correlation and dependence">Correlation</a></li><li><a href="Regression_analysis" title="Regression analysis">Regression analysis</a></li></ul></div></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Correlation_and_dependence" class="mw-redirect" title="Correlation and dependence">Correlation</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Pearson_product-moment_correlation_coefficient" class="mw-redirect" title="Pearson product-moment correlation coefficient">Pearson product-moment</a></li>

<li><a href="Partial_correlation" title="Partial correlation">Partial correlation</a></li>

<li><a href="Confounding" title="Confounding">Confounding variable</a></li>

<li><a href="Coefficient_of_determination" title="Coefficient of determination">Coefficient of determination</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Regression_analysis" title="Regression analysis">Regression analysis</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Errors_and_residuals" title="Errors and residuals">Errors and residuals</a></li>

<li><a href="Regression_validation" title="Regression validation">Regression validation</a></li>

<li><a href="Mixed_model" title="Mixed model">Mixed effects models</a></li>

<li><a href="Simultaneous_equations_model" title="Simultaneous equations model">Simultaneous equations models</a></li>

<li><a href="Multivariate_adaptive_regression_splines" class="mw-redirect" title="Multivariate adaptive regression splines">Multivariate adaptive regression splines (MARS)</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Linear_regression" title="Linear regression">Linear regression</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Simple_linear_regression" title="Simple linear regression">Simple linear regression</a></li>

<li><a href="Ordinary_least_squares" title="Ordinary least squares">Ordinary least squares</a></li>

<li><a href="General_linear_model" title="General linear model">General linear model</a></li>

<li><a href="Bayesian_linear_regression" title="Bayesian linear regression">Bayesian regression</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em">Non-standard predictors</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Nonlinear_regression" title="Nonlinear regression">Nonlinear regression</a></li>

<li><a href="Nonparametric_regression" title="Nonparametric regression">Nonparametric</a></li>

<li><a href="Semiparametric_regression" title="Semiparametric regression">Semiparametric</a></li>

<li><a href="Isotonic_regression" title="Isotonic regression">Isotonic</a></li>

<li><a href="Robust_regression" title="Robust regression">Robust</a></li>

<li><a href="Homoscedasticity_and_heteroscedasticity" title="Homoscedasticity and heteroscedasticity">Homoscedasticity and Heteroscedasticity</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Generalized_linear_model" title="Generalized linear model">Generalized linear model</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Exponential_family" title="Exponential family">Exponential families</a></li>

<li><a href="Logistic_regression" title="Logistic regression">Logistic <span style="font-size: 85%;">(Bernoulli)</span></a> / <a href="Binomial_regression" title="Binomial regression">Binomial</a> / <a href="Poisson_regression" title="Poisson regression">Poisson regressions</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Partition_of_sums_of_squares" title="Partition of sums of squares">Partition of variance</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Analysis_of_variance" title="Analysis of variance">Analysis of variance (ANOVA, anova)</a></li>

<li><a href="Analysis_of_covariance" title="Analysis of covariance">Analysis of covariance</a></li>

<li><a href="Multivariate_analysis_of_variance" title="Multivariate analysis of variance">Multivariate ANOVA</a></li>

<li><a href="Degrees_of_freedom_(statistics)" title="Degrees of freedom (statistics)">Degrees of freedom</a></li></ul>

</div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Categorical_/_multivariate_/_time-series_/_survival_analysis654" style="font-size:114%;margin:0 4em"><a href="Categorical_variable" title="Categorical variable">Categorical</a> / <a href="Multivariate_statistics" title="Multivariate statistics">multivariate</a> / <a href="Time_series" title="Time series">time-series</a> / <a href="Survival_analysis" title="Survival analysis">survival analysis</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Categorical_variable" title="Categorical variable">Categorical</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Cohen's_kappa" title="Cohen's kappa">Cohen's kappa</a></li>

<li><a href="Contingency_table" title="Contingency table">Contingency table</a></li>

<li><a href="Graphical_model" title="Graphical model">Graphical model</a></li>

<li><a href="Poisson_regression" title="Poisson regression">Log-linear model</a></li>

<li><a href="McNemar's_test" title="McNemar's test">McNemar's test</a></li>

<li><a href="Cochran%E2%80%93Mantel%E2%80%93Haenszel_statistics" title="Cochran–Mantel–Haenszel statistics">Cochran–Mantel–Haenszel statistics</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Multivariate_statistics" title="Multivariate statistics">Multivariate</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="General_linear_model" title="General linear model">Regression</a></li>

<li><a href="Multivariate_analysis_of_variance" title="Multivariate analysis of variance">Manova</a></li>

<li><a href="Principal_component_analysis" title="Principal component analysis">Principal components</a></li>

<li><a href="Canonical_correlation" title="Canonical correlation">Canonical correlation</a></li>

<li><a href="Linear_discriminant_analysis" title="Linear discriminant analysis">Discriminant analysis</a></li>

<li><a href="Cluster_analysis" title="Cluster analysis">Cluster analysis</a></li>

<li><a href="Statistical_classification" title="Statistical classification">Classification</a></li>

<li><a href="Structural_equation_modeling" title="Structural equation modeling">Structural equation model</a>

<ul><li><a href="Factor_analysis" title="Factor analysis">Factor analysis</a></li></ul></li>

<li><a href="Multivariate_distribution" class="mw-redirect" title="Multivariate distribution">Multivariate distributions</a>

<ul><li><a href="Elliptical_distribution" title="Elliptical distribution">Elliptical distributions</a>

<ul><li><a href="Multivariate_normal_distribution" title="Multivariate normal distribution">Normal</a></li></ul></li></ul></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Time_series" title="Time series">Time-series</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;font-weight:normal;">General</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Decomposition_of_time_series" title="Decomposition of time series">Decomposition</a></li>

<li><a href="Trend_estimation" class="mw-redirect" title="Trend estimation">Trend</a></li>

<li><a href="Stationary_process" title="Stationary process">Stationarity</a></li>

<li><a href="Seasonal_adjustment" title="Seasonal adjustment">Seasonal adjustment</a></li>

<li><a href="Exponential_smoothing" title="Exponential smoothing">Exponential smoothing</a></li>

<li><a href="Cointegration" title="Cointegration">Cointegration</a></li>

<li><a href="Structural_break" title="Structural break">Structural break</a></li>

<li><a href="Granger_causality" title="Granger causality">Granger causality</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;font-weight:normal;">Specific tests</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Dickey%E2%80%93Fuller_test" title="Dickey–Fuller test">Dickey–Fuller</a></li>

<li><a href="Johansen_test" title="Johansen test">Johansen</a></li>

<li><a href="Ljung%E2%80%93Box_test" title="Ljung–Box test">Q-statistic <span style="font-size: 85%;">(Ljung–Box)</span></a></li>

<li><a href="Durbin%E2%80%93Watson_statistic" title="Durbin–Watson statistic">Durbin–Watson</a></li>

<li><a href="Breusch%E2%80%93Godfrey_test" title="Breusch–Godfrey test">Breusch–Godfrey</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;font-weight:normal;"><a href="Time_domain" title="Time domain">Time domain</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Autocorrelation" title="Autocorrelation">Autocorrelation (ACF)</a>

<ul><li><a href="Partial_autocorrelation_function" title="Partial autocorrelation function">partial (PACF)</a></li></ul></li>

<li><a href="Cross-correlation" title="Cross-correlation">Cross-correlation (XCF)</a></li>

<li><a href="Autoregressive%E2%80%93moving-average_model" class="mw-redirect" title="Autoregressive–moving-average model">ARMA model</a></li>

<li><a href="Box%E2%80%93Jenkins_method" title="Box–Jenkins method">ARIMA model <span style="font-size: 85%;">(Box–Jenkins)</span></a></li>

<li><a href="Autoregressive_conditional_heteroskedasticity" title="Autoregressive conditional heteroskedasticity">Autoregressive conditional heteroskedasticity (ARCH)</a></li>

<li><a href="Vector_autoregression" title="Vector autoregression">Vector autoregression (VAR)</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;font-weight:normal;"><a href="Frequency_domain" title="Frequency domain">Frequency domain</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Spectral_density_estimation" title="Spectral density estimation">Spectral density estimation</a></li>

<li><a href="Fourier_analysis" title="Fourier analysis">Fourier analysis</a></li>

<li><a href="Least-squares_spectral_analysis" title="Least-squares spectral analysis">Least-squares spectral analysis</a></li>

<li><a href="Wavelet" title="Wavelet">Wavelet</a></li>

<li><a href="Whittle_likelihood" title="Whittle likelihood">Whittle likelihood</a></li></ul>

</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Survival_analysis" title="Survival analysis">Survival</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;font-weight:normal;"><a href="Survival_function" title="Survival function">Survival function</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Kaplan%E2%80%93Meier_estimator" title="Kaplan–Meier estimator">Kaplan–Meier estimator (product limit)</a></li>

<li><a href="Proportional_hazards_model" title="Proportional hazards model">Proportional hazards models</a></li>

<li><a href="Accelerated_failure_time_model" title="Accelerated failure time model">Accelerated failure time (AFT) model</a></li>

<li><a href="First-hitting-time_model" title="First-hitting-time model">First hitting time</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;font-weight:normal;"><a href="Failure_rate" title="Failure rate">Hazard function</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Nelson%E2%80%93Aalen_estimator" title="Nelson–Aalen estimator">Nelson–Aalen estimator</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;font-weight:normal;">Test</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

</div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Applications654" style="font-size:114%;margin:0 4em"><a href="List_of_fields_of_application_of_statistics" title="List of fields of application of statistics">Applications</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Biostatistics" title="Biostatistics">Biostatistics</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Bioinformatics" title="Bioinformatics">Bioinformatics</a></li>

<li><a href="Clinical_trial" title="Clinical trial">Clinical trials</a> / <a href="Clinical_study_design" title="Clinical study design">studies</a></li>

<li><a href="Epidemiology" title="Epidemiology">Epidemiology</a></li>

<li><a href="Medical_statistics" title="Medical statistics">Medical statistics</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Engineering_statistics" title="Engineering statistics">Engineering statistics</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Chemometrics" title="Chemometrics">Chemometrics</a></li>

<li><a href="Methods_engineering" title="Methods engineering">Methods engineering</a></li>

<li><a href="Probabilistic_design" title="Probabilistic design">Probabilistic design</a></li>

<li><a href="Statistical_process_control" title="Statistical process control">Process</a> / <a href="Quality_control" title="Quality control">quality control</a></li>

<li><a href="Reliability_engineering" title="Reliability engineering">Reliability</a></li>

<li><a href="System_identification" title="System identification">System identification</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Social_statistics" title="Social statistics">Social statistics</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Actuarial_science" title="Actuarial science">Actuarial science</a></li>

<li><a href="Census" title="Census">Census</a></li>

<li><a href="Crime_statistics" title="Crime statistics">Crime statistics</a></li>

<li><a href="Demographic_statistics" title="Demographic statistics">Demography</a></li>

<li><a href="Econometrics" title="Econometrics">Econometrics</a></li>

<li><a href="Jurimetrics" title="Jurimetrics">Jurimetrics</a></li>

<li><a href="National_accounts" title="National accounts">National accounts</a></li>

<li><a href="Official_statistics" title="Official statistics">Official statistics</a></li>

<li><a href="Population_statistics" class="mw-redirect" title="Population statistics">Population statistics</a></li>

<li><a href="Psychometrics" title="Psychometrics">Psychometrics</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:12.5em"><a href="Spatial_analysis" title="Spatial analysis">Spatial statistics</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Cartography" title="Cartography">Cartography</a></li>

<li><a href="Environmental_statistics" title="Environmental statistics">Environmental statistics</a></li>

<li><a href="Geographic_information_system" title="Geographic information system">Geographic information system</a></li>

<li><a href="Geostatistics" title="Geostatistics">Geostatistics</a></li>

<li><a href="Kriging" title="Kriging">Kriging</a></li></ul>

</div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div>

<ul><li><span class="noviewer" typeof="mw:File"><span title="Category"></span></span><b>Category</b></li>

<li><b><span class="nowrap"><span class="skin-invert-image noviewer" typeof="mw:File"></span> </span><a href="Portal%3AMathematics" title="Portal:Mathematics">Mathematics portal</a></b></li>

<li><span class="noviewer" typeof="mw:File"><span title="Commons page"></span></span><b><a href="https://commons.wikimedia.org/wiki/Category:Statistics" class="extiw external" title="commons:Category:Statistics">Commons</a></b></li>

<li><span class="noviewer" typeof="mw:File"><span title="WikiProject"></span></span> <b>WikiProject</b></li></ul>

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This article is issued from <a class="external text" title="Last edited on 2025-06-24" href="https://en.wikipedia.org/wiki/?title=Scientific_control&oldid=1297172849">Wikipedia</a>. The text is available under <a class="external text" href="https://creativecommons.org/licenses/by-sa/4.0/deed.en">Creative Commons Attribution-Share Alike 4.0</a> unless otherwise noted. Additional terms may apply for the media files.

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